Protein Details: Calcium-activated chloride channel regulator 1

Protein ID

ICDB_Pro_1650

Protein Name

Calcium-activated chloride channel regulator 1

Gene Name

CLCA1; AECC

Organism

Sus scrofa (Pig)

Length

917 amino acids

AlphaFoldDB

AF-Q9TUB5-F1-model_v4.pdb

Function

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia; mucus hypersecretion; cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells.

Sequence

MGSFRSSLFILVLHLLEGAQSNSLIQLNGNGYEGIVIAIDPNVPEDERLIQNIKDMVTKASPYLFEATEKRFYFKNVAILIPASWKAKPEYVKPKLETYKNADVVVTEPNPPENDGPYTEQMGNCGEKGEKIYFTPDFVAGKKVLQYGPQGRVFVHEWAHLRWGVFNEYNNEQKFYLSNKKEQPVICSAAIRGTNVLPQCQGGSCVTKPCRADRVTGLFQKECEFIPDPQQSEKASIMFAQSIDTVVEFCKEKNHNKEAPNDQNQKCNLRSTWEVIQDSEDFKKTTPMTTQPPAPTFSLLQIGQRIVCLVLDKSGSMTVGGRLKRLNQAGKLFLLQTVEQGAWVGMVAFDSAAYVKSELVQINSAAERDALARSLPTAASGGTSICSGLRSAFTVIKKKYPTDGSEIVLLTDGEDNTISACFPEVKQNGAIIHTVALGPSAAKELEELSQMTGGLQTYASDQAENNGLIDAFGALSSGNRAASQRSIQLESQGLTLQNNEWMNGTVVVDSTVGKDTLFLITLERKFLSPIPFFGVPSGRSQDSFLVGKHNKMAYFQVPGTAKVGMWKYSLQASSQTLTLTVSSRRSSATLPPVTVTSKMNKDTGKFPSPMVVYTKIHQGTLPILRAKVTALIESENGKTVTLELLDNGAGADATKNDGIYSRYFTAYDANGRYSVKVWALGGVNTPRRRAPPLWSGAMYIRGWIENGEIKWNPPRPDINKDDLQGKQVCFSRTASGGSFVASDVPKSPIPDLFPPCKITDLKAGIQGDNLINLTWTAPGDDYDHGRADRYIIRISTNILDLRDKFNDSVQVNTTDLIPKEANSEEVFVFKPEGIPFTNGTDLFIAVQAVDKTNLKSEISNIAQVSLFLPPEAPPETPPETPAPSLPCPEIQVNSTIPGIHILKIMWKWLGELQLSIA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 156; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 160; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 167; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Location

Expressed in ileum; trachea; and the major salivary glands; In ileum; expressed to the crypt and villus epithelia; whereas in trachea expressed in both surface epithelium and submucosal glands

DOI ID

10.1152/physiolgenomics.2000.3.2.101; 10.1152/ajpcell.00477.2001; 10.1016/s0006-291x(02)02498-1; 10.1152/ajpgi.00023.2004

RefSeq

NP_999313.1